High-Resolution Two-Field Nuclear Magnetic Resonance Spectroscopy

Samuel F Cousin (1) , Cyril Charlier (1) , Pavel Kadeřávek (1) , Thorsten Marquardsen (2) , Jean-­max Tyburn (3) , Pierre-­alain Bovier (4) , Simone Ulzega (4) , Thomas Speck (4) , Dirk Wilhelm (4) , Frank F Engelke (2) , Werner Maas (5) , Dimitrios Sakellariou (6) , Geoffrey Bodenhausen (1) , Philippe Pelupessy (1) , Fabien F Ferrage (1)

1 LBM-E3 - Structure et Dynamique des Biomolécules
2 Bruker BioSpin GmbH, D-76287 Rheinstetten, Germany
3 Bruker BioSpin [Wissembourg]
4 Bruker Biospin AG
5 Bruker BioSpin [Billerica, MA]
6 LSDRM - Laboratoire Structure et Dynamique par Résonance Magnétique (LCF)

Nuclear Magnetic Resonance (NMR) is a ubiquitous branch of spectroscopy that can explore matter on the scale of the atom. Significant improvements in sensitivity and resolution have been driven by a steady increase of static magnetic field strengths. However, some properties of nuclei may be more favourable at low magnetic fields. For example, line-broadening due to chemical shift anisotropy increases sharply at higher magnetic fields. Here, we present a two-field NMR spectrometer that permits the application of rf-pulses and acquisition of NMR signals in two magnetic centres. Our prototype operates at 14.1 T and 0.33 T. The main features of this system are demonstrated by novel NMR experiments that correlate zero-quantum coherences at low magnetic field with single quantum coherences at high magnetic field, so that high resolution can be achieved in both dimensions, despite a ca. 10 ppm inhomogeneity of the low field centre. Two-field NMR spectroscopy offers the possibility to circumvent the limits of high magnetic fields, while benefiting from their exceptional sensitivity and resolution. This approach opens new avenues for NMR above 1 GHz.

Domaines: Matériaux

Samuel F Cousin, Cyril Charlier, Pavel Kadeřávek, Thorsten Marquardsen, Jean-­max Tyburn, et al.. High-Resolution Two-Field Nuclear Magnetic Resonance Spectroscopy. Physical Chemistry Chemical Physics, 2016, 18, pp.33187-33194. ⟨10.1039/C6CP05422F⟩. ⟨cea-01393871⟩