Biocompatible Stimuli-Responsive W/O/W Multiple Emulsions Prepared by One-Step Mixing with a Single Diblock Copolymer Emulsifier

Abstract : Multiple water-in-oil-in-water (W/O/W) emulsions are promising materials in designing carriers of hydrophilic molecules or drug delivery systems, provided stability issues are solved and biocompatible chemicals can be used. In this work, we designed a biocompatible amphiphilic copolymer, poly(dimethylsiloxane)-b-poly(2-(dimethylamino)ethyl methacrylate) (PDMS-b-PDMAE-MA), that can stabilize emulsions made with various biocompatible oils. The hydrophilic/hydrophobic properties of the copolymer can be adjusted using both pH and ionic strength stimuli. Consequently, the making of O/W (oil in water), W/O (water in oil), and W/O/W emulsions can be achieved by sweeping the pH and ionic strength. Of importance, W/O/W emulsions are formulated over a large pH and ionic strength domain in a one-step emulsification process via transitional phase inversion and are stable for several months. Cryo-TEM and interfacial tension studies show that the formation of these W/O/W emulsions is likely to be correlated to the interfacial film curvature and microemulsion morphology.
Type de document :
Article dans une revue
Langmuir, American Chemical Society, 2016, 32, pp.10912 - 10919. 〈http://pubs.acs.org/doi/abs/10.1021/acs.langmuir.6b02590〉. 〈10.1021/acs.langmuir.6b02590〉
Domaine :
Liste complète des métadonnées

Littérature citée [36 références]  Voir  Masquer  Télécharger

https://hal-cea.archives-ouvertes.fr/cea-01387471
Contributeur : Serge Palacin <>
Soumis le : lundi 12 décembre 2016 - 13:59:27
Dernière modification le : mardi 27 mars 2018 - 16:06:21
Document(s) archivé(s) le : lundi 27 mars 2017 - 16:48:35

Fichier

Protat_2016_Biocompatible.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Citation

Marine Protat, Noémie Bodin, Frédéric Gobeaux, Florent Malloggi, Jean Daillant, et al.. Biocompatible Stimuli-Responsive W/O/W Multiple Emulsions Prepared by One-Step Mixing with a Single Diblock Copolymer Emulsifier. Langmuir, American Chemical Society, 2016, 32, pp.10912 - 10919. 〈http://pubs.acs.org/doi/abs/10.1021/acs.langmuir.6b02590〉. 〈10.1021/acs.langmuir.6b02590〉. 〈cea-01387471〉

Partager

Métriques

Consultations de la notice

218

Téléchargements de fichiers

96