Biocompatible Stimuli-Responsive W/O/W Multiple Emulsions Prepared by One-Step Mixing with a Single Diblock Copolymer Emulsifier

Marine Protat (1, 2) , Noémie Bodin (1, 2) , Frédéric Gobeaux (1) , Florent Malloggi (1) , Jean Daillant (3) , Nadège Pantoustier (2) , Patrick Guenoun (1) , Patrick Perrin (2)

1 LIONS - Laboratoire Interdisciplinaire sur l'Organisation Nanométrique et Supramoléculaire
2 SIMM - Sciences et Ingénierie de la Matière Molle
3 SSOLEIL - Synchrotron SOLEIL

Multiple water-in-oil-in-water (W/O/W) emulsions are promising materials in designing carriers of hydrophilic molecules or drug delivery systems, provided stability issues are solved and biocompatible chemicals can be used. In this work, we designed a biocompatible amphiphilic copolymer, poly(dimethylsiloxane)-b-poly(2-(dimethylamino)ethyl methacrylate) (PDMS-b-PDMAE-MA), that can stabilize emulsions made with various biocompatible oils. The hydrophilic/hydrophobic properties of the copolymer can be adjusted using both pH and ionic strength stimuli. Consequently, the making of O/W (oil in water), W/O (water in oil), and W/O/W emulsions can be achieved by sweeping the pH and ionic strength. Of importance, W/O/W emulsions are formulated over a large pH and ionic strength domain in a one-step emulsification process via transitional phase inversion and are stable for several months. Cryo-TEM and interfacial tension studies show that the formation of these W/O/W emulsions is likely to be correlated to the interfacial film curvature and microemulsion morphology.

Domains: Chemical Sciences; Material chemistry

Marine Protat, Noémie Bodin, Frédéric Gobeaux, Florent Malloggi, Jean Daillant, et al.. Biocompatible Stimuli-Responsive W/O/W Multiple Emulsions Prepared by One-Step Mixing with a Single Diblock Copolymer Emulsifier. Langmuir, 2016, 32, pp.10912 - 10919. ⟨10.1021/acs.langmuir.6b02590⟩. ⟨cea-01387471⟩