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Review of Actinide Decorporation with Chelating Agents

Abstract : In case of accidental release of radionuclides in a nuclear facility or in the environment, internal contamination (inhalation, in-gestion or wound) with actinides represents a severe health risk to human beings. It is therefore important to provide effective che-lation therapy or decorporation to reduce acute radiation damage, chemical toxicity, and late radiation effects. Speciation governs bioavailability and toxicity of elements and it is a prerequisite tool for the design and success of new ligands or chelating agents. The purpose of this review is to present the state-of-the-art of actinide decorporation within biological media, to recall briefly actinide metabolism, to list the basic constraints of actinideeligand for development, to describe main tools developed and used for decorporation studies, to review mainly the chelating agents tested for actinides, and finally to conclude on the future trends in this field. To cite this article: E ´. Ansoborlo et al., C. R. Chimie X 33 (2007). Ó 2007 Académie des sciences. Published by Elsevier Masson SAS. All rights reserved.
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Éric Ansoborlo, Badia Amekraz, Christophe Moulin, Valérie Moulin, Frédéric Taran, et al.. Review of Actinide Decorporation with Chelating Agents. Comptes Rendus. Chimie, Académie des sciences (Paris), 2007, 10 (10-11), pp.1010-1019. ⟨10.1016/j.crci.2007.01.015⟩. ⟨cea-01273033⟩



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