Nitric oxide as a unique signaling molecule in the vascular system: a historical overview, J. Physiol. Pharmacol, vol.53, pp.503-514, 2002. ,
Nitric oxide synthases: structure, function and inhibition, Biochemical Journal, vol.357, issue.3, pp.593-615, 2001. ,
DOI : 10.1042/bj3570593
Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain, FEBS Journal, vol.42, issue.15, pp.3959-3974, 2009. ,
DOI : 10.1111/j.1742-4658.2009.07120.x
Intrinsic and Extrinsic Modulation of Nitric Oxide Synthase Activity, Chemical Reviews, vol.102, issue.4, pp.1179-1190, 2002. ,
DOI : 10.1021/cr000661e
Nitric oxide synthase is a cytochrome P-450 type hemoprotein, Biochemistry, vol.31, issue.29, pp.6627-6631, 1992. ,
DOI : 10.1021/bi00144a001
Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate, Science, vol.279, issue.5359, pp.2121-2126, 1998. ,
DOI : 10.1126/science.279.5359.2121
Tetrahydrobiopterin Radical Enzymology, Chemical Reviews, vol.103, issue.6, pp.2365-2383, 2003. ,
DOI : 10.1021/cr0204350
Identification of Nitric Oxide Synthase as a Thiolate-ligated Heme Protein Using Magnetic Circular Dichroism Spectroscopy: COMPARISON WITH CYTOCHROME P-450-CAM AND CHLOROPEROXIDASE, Journal of Biological Chemistry, vol.270, issue.34, pp.19943-19948, 1995. ,
DOI : 10.1074/jbc.270.34.19943
Heme-Containing Oxygenases, Chemical Reviews, vol.96, issue.7, pp.2841-2888, 1996. ,
DOI : 10.1021/cr9500500
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes, Chemical Reviews, vol.104, issue.9, pp.3947-3980, 2004. ,
DOI : 10.1021/cr020443g
Catalysis by nitric oxide synthase, Current Opinion in Chemical Biology, vol.2, issue.5, pp.656-663, 1998. ,
DOI : 10.1016/S1367-5931(98)80098-7
N omega-hydroxy-Larginine is an intermediate in the biosynthesis of nitric oxide from L-arginine, J. Biol. Chem, vol.266, pp.6259-6263, 1991. ,
L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen, J. Biol. Chem, vol.265, pp.13442-13445, 1990. ,
Structural biology of heme monooxygenases, Biochemical and Biophysical Research Communications, vol.338, issue.1, pp.337-345, 2005. ,
DOI : 10.1016/j.bbrc.2005.07.204
Structure?function studies on nitric oxide synthases, Journal of Inorganic Biochemistry, vol.99, issue.1, pp.293-305, 2005. ,
DOI : 10.1016/j.jinorgbio.2004.10.016
Catalytic Reduction of a Tetrahydrobiopterin Radical within Nitric-oxide Synthase, Journal of Biological Chemistry, vol.283, issue.17, pp.11734-11742, 2008. ,
DOI : 10.1074/jbc.M709250200
The Second Step of the Nitric Oxide Synthase Reaction: Evidence for Ferric-Peroxo as the Active Oxidant, Journal of the American Chemical Society, vol.131, issue.1, pp.297-305, 2009. ,
DOI : 10.1021/ja807299t
The molecular mechanism of mammalian NO-synthases: A story of electrons and protons, Journal of Inorganic Biochemistry, vol.105, issue.2, pp.127-141, 2011. ,
DOI : 10.1016/j.jinorgbio.2010.10.011
URL : https://hal.archives-ouvertes.fr/hal-00721814
Reaction of Neuronal Nitric-oxide Synthase with Oxygen at Low Temperature: EVIDENCE FOR REDUCTIVE ACTIVATION OF THE OXY-FERROUS COMPLEX BY TETRAHYDROBIOPTERIN, Journal of Biological Chemistry, vol.273, issue.22, pp.13502-13508, 1998. ,
DOI : 10.1074/jbc.273.22.13502
Rapid Kinetic Studies Link Tetrahydrobiopterin Radical Formation to Heme-dioxy Reduction and Arginine Hydroxylation in Inducible Nitric-oxide Synthase, Journal of Biological Chemistry, vol.276, issue.1, pp.315-319, 2001. ,
DOI : 10.1074/jbc.M008441200
The Three Nitric-oxide Synthases Differ in Their Kinetics of Tetrahydrobiopterin Radical Formation, Heme-Dioxy Reduction, and Arginine Hydroxylation, Journal of Biological Chemistry, vol.280, issue.10, pp.8929-8935, 2005. ,
DOI : 10.1074/jbc.M409737200
Nitric Oxide Synthase Stabilizes the Tetrahydrobiopterin Cofactor Radical by Controlling Its Protonation State, Journal of the American Chemical Society, vol.132, issue.33, pp.11812-11823, 2010. ,
DOI : 10.1021/ja105372s
A Tetrahydrobiopterin Radical Forms and then Becomes Reduced during N??-Hydroxyarginine Oxidation by Nitric-oxide Synthase, Journal of Biological Chemistry, vol.278, issue.47, pp.46668-46673, 2003. ,
DOI : 10.1074/jbc.M307682200
Bacterial nitric oxide synthases: what are they good for? Trends Microbiol, pp.212-218, 2009. ,
DOI : 10.1016/j.tim.2009.02.003
Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans, Proc. Natl. Acad. Sci. USA, pp.107-112, 2002. ,
DOI : 10.1073/pnas.012470099
Crystal Structure of SANOS, a Bacterial Nitric Oxide Synthase Oxygenase Protein from Staphylococcus aureus, Structure, vol.10, issue.12, pp.1687-1696, 2002. ,
DOI : 10.1016/S0969-2126(02)00911-5
Bacterial Nitric Oxide Synthases, Annual Review of Biochemistry, vol.79, issue.1, pp.445-470, 2010. ,
DOI : 10.1146/annurev-biochem-062608-103436
Direct Evidence for Nitric Oxide Production by a Nitric-oxide Synthase-like Protein from Bacillus subtilis, Journal of Biological Chemistry, vol.277, issue.18, pp.16167-16171, 2002. ,
DOI : 10.1074/jbc.M201136200
The ferric form of the three human embryonic hemoglobins and their reactions with azide ions, Journal of Inorganic Biochemistry, vol.81, issue.1-2, pp.99-103, 2000. ,
DOI : 10.1016/S0162-0134(00)00116-1
??ber Pterinchemie 23. Mitteilung [1]. Radikalbildung w??hrend der Oxydation von Tetrahydrofols??ure und 5,6,7,8-Tetrahydropterin, Helvetica Chimica Acta, vol.50, issue.8, pp.2222-2225, 1967. ,
DOI : 10.1002/hlca.19670500807
3-mm High-field EPR on semiquinone radical anions Q.cntdot.- related to photosynthesis and on the primary donor P.cntdot.+ and acceptor QA.cntdot.- in reaction centers of Rhodobacter sphaeroides R-26, The Journal of Physical Chemistry, vol.97, issue.29, pp.7639-7647, 1993. ,
DOI : 10.1021/j100131a037
EasySpin, a comprehensive software package for spectral simulation and analysis in EPR, Journal of Magnetic Resonance, vol.178, issue.1, pp.42-55, 2006. ,
DOI : 10.1016/j.jmr.2005.08.013
Nitric-oxide synthase: A cytochrome P450 family foster child, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1770, issue.3, pp.432-445, 2007. ,
DOI : 10.1016/j.bbagen.2006.08.019
Single-turnover of Nitric-oxide Synthase in the Presence of 4-Amino-tetrahydrobiopterin: PROPOSED ROLE FOR TETRAHYDROBIOPTERIN AS A PROTON DONOR, Journal of Biological Chemistry, vol.278, issue.49, pp.48602-48610, 2003. ,
DOI : 10.1074/jbc.M305682200
Formation of a protonated trihydrobiopterin radical cation in the first reaction cycle of neuronal and endothelial nitric oxide synthase detected by electron paramagnetic resonance spectroscopy, JBIC Journal of Biological Inorganic Chemistry, vol.6, issue.2, pp.151-158, 2001. ,
DOI : 10.1007/s007750000185
Substrate-specific Interactions with the Heme-bound Oxygen Molecule of Nitric-oxide Synthase, Journal of Biological Chemistry, vol.282, issue.29, 2007. ,
DOI : 10.1074/jbc.M701800200
Substrate- and Isoform-Specific Dioxygen Complexes of Nitric Oxide Synthase, Journal of the American Chemical Society, vol.129, issue.21, pp.6943-6951, 2007. ,
DOI : 10.1021/ja070683j
Pterin-Centered Radical as a Mechanistic Probe of the Second Step of Nitric Oxide Synthase, Journal of the American Chemical Society, vol.132, issue.14, pp.5105-5113, 2010. ,
DOI : 10.1021/ja909378n
A Conserved Val to Ile Switch near the Heme Pocket of Animal and Bacterial Nitric-oxide Synthases Helps Determine Their Distinct Catalytic Profiles, Journal of Biological Chemistry, vol.279, issue.18, pp.19018-19025, 2004. ,
DOI : 10.1074/jbc.M311663200
Revisiting Heme Mechanisms. A Perspective on the Mechanisms of Nitric Oxide Synthase (NOS), Heme Oxygenase (HO), and Cytochrome P450s (CYP450s), Heme oxygenase (HO), and cytochrome P450s (CYP450s), pp.2231-2243, 2008. ,
DOI : 10.1021/bi7023817
Second Half-Reaction of Nitric Oxide Synthase:?? Computational Insights into the Initial Step and Key Proposed Intermediate, The Journal of Physical Chemistry B, vol.109, issue.49, pp.23706-23714, 2005. ,
DOI : 10.1021/jp054864o
A Density Functional Theory Investigation on the Mechanism of the Second Half-Reaction of Nitric Oxide Synthase, Journal of the American Chemical Society, vol.130, issue.11, pp.3328-3334, 2008. ,
DOI : 10.1021/ja072650+
The Proximal Hydrogen Bond Network Modulates Bacillus subtilis Nitric-oxide Synthase Electronic and Structural Properties, Journal of Biological Chemistry, vol.286, issue.14, pp.11997-12005, 2011. ,
DOI : 10.1074/jbc.M110.195446
URL : https://hal.archives-ouvertes.fr/hal-00720044