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Journal Articles Nature Year : 2010

A human gut microbial gene catalogue established by metagenomic sequencing

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Trine Nielsen
Nicolas Pons
  • Function : Author
Florence Levenez
  • Function : Author
Bo Wang
Torben Hansen
Eric Pelletier
Yan Zhou
Nan Qin
  • Function : Author
  • PersonId : 948947
Jian Wang
  • Function : Author
  • PersonId : 737345
  • IdHAL : jian-wang
Joel Doré
  • Function : Author
Karsten Kristiansen
S. Dusko Ehrlich
  • Function : Correspondent author

Abstract

To understand the impact of gut microbes on human health and well-being it is crucial to assess their genetic potential. Here we describe the Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals. The gene set, ~150 times larger than the human gene complement, contains an overwhelming majority of the prevalent (more frequent) microbial genes of the cohort and probably includes a large proportion of the prevalent human intestinal microbial genes. The genes are largely shared among individuals of the cohort. Over 99% of the genes are bacterial, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species, which are also largely shared. We define and describe the minimal gut metagenome and the minimal gut bacterial genome in terms of functions present in all individuals and most bacteria, respectively
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Dates and versions

cea-00908974 , version 1 (16-10-2019)

Licence

Attribution - NonCommercial - ShareAlike - CC BY 4.0

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Junjie Qin, Ruiqiang Li, Jeroen Raes, Manimozhiyan Arumugam, Kristoffer Solvsten Burgdorf, et al.. A human gut microbial gene catalogue established by metagenomic sequencing. Nature, 2010, 464 (7285), pp. 59-65. ⟨10.1038/nature08821⟩. ⟨cea-00908974⟩
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