A human gut microbial gene catalogue established by metagenomic sequencing
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Manimozhiyan Arumugam
- Function : Author
- PersonId : 770023
- ORCID : 0000-0002-0886-9101
Trine Nielsen
- Function : Author
- PersonId : 770024
- ORCID : 0000-0002-2066-7895
Junhua Li
- Function : Author
- PersonId : 770145
- ORCID : 0000-0001-6784-1873
Bo Wang
- Function : Author
- PersonId : 761439
- ORCID : 0000-0002-5579-6830
Julien Tap
- Function : Author
- PersonId : 1172956
- IdHAL : julien-tap
- ORCID : 0000-0001-8998-5413
Patricia Lepage
- Function : Author
- PersonId : 748833
- IdHAL : patricia-lepage
- ORCID : 0000-0002-9501-6771
- IdRef : 096241063
Torben Hansen
- Function : Author
- PersonId : 758676
- ORCID : 0000-0001-8748-3831
Eric Pelletier
- Function : Author
- PersonId : 183144
- IdHAL : eric
- ORCID : 0000-0003-4228-1712
- IdRef : 250792974
Yan Zhou
- Function : Author
- PersonId : 759080
- ORCID : 0000-0001-5641-9191
Joel Doré
- Function : Author
Karsten Kristiansen
- Function : Author
- PersonId : 757952
- ORCID : 0000-0002-6024-0917
Oluf Pedersen
- Function : Author
- PersonId : 1070332
S. Dusko Ehrlich
- Function : Correspondent author
Abstract
To understand the impact of gut microbes on human health and well-being it is crucial to assess their genetic potential. Here we describe the Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals. The gene set, ~150 times larger than the human gene complement, contains an overwhelming majority of the prevalent (more frequent) microbial genes of the cohort and probably includes a large proportion of the prevalent human intestinal microbial genes. The genes are largely shared among individuals of the cohort. Over 99% of the genes are bacterial, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species, which are also largely shared. We define and describe the minimal gut metagenome and the minimal gut bacterial genome in terms of functions present in all individuals and most bacteria, respectively
Origin : Publication funded by an institution
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