 |
Journal articles
A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response
Abstract : Intracellular pathogens such as $Listeria\ monocytogenes$ subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon IFN-stimulated genes (ISGs). IFN-$\lambda$ expression was induced in response to infection of epithelial cells with bacteria lacking LntA; however, the BAHD1-chromatin associated complex repressed downstream ISGs. In contrast, in cells infected with lntA-expressing bacteria, LntA prevented BAHD1 recruitment to ISGs and stimulated their expression. Murine listeriosis decreased in $BAHD1$ +/- mice or when $lntA$ was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-$\lambda$-mediated immune response to control bacterial colonization of the host.
Cited literature [63 references]
https://hal-cea.archives-ouvertes.fr/cea-00819299
Contributor : Bruno Savelli <>
Submitted on : Sunday, July 26, 2020 - 6:01:03 PM
Last modification on : Wednesday, June 2, 2021 - 4:27:02 PM
Contributor : Bruno Savelli <>
Submitted on : Sunday, July 26, 2020 - 6:01:03 PM
Last modification on : Wednesday, June 2, 2021 - 4:27:02 PM
File
Science_2011_post-print.pdf
Files produced by the author(s)