A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response
Abstract
Intracellular pathogens such as $Listeria\ monocytogenes$ subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon IFN-stimulated genes (ISGs). IFN-$\lambda$ expression was induced in response to infection of epithelial cells with bacteria lacking LntA; however, the BAHD1-chromatin associated complex repressed downstream ISGs. In contrast, in cells infected with $lntA$-expressing bacteria, LntA prevented BAHD1 recruitment to ISGs and stimulated their expression. Murine listeriosis decreased in BAHD1$^{+/-}$ mice or when $lntA$ was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-$\lambda$-mediated immune response to control bacterial colonization of the host.
Domains
Life Sciences [q-bio] Cellular Biology Subcellular Processes [q-bio.SC] Life Sciences [q-bio] Biochemistry, Molecular Biology Molecular biology Life Sciences [q-bio] Biochemistry, Molecular Biology Structural Biology [q-bio.BM] Life Sciences [q-bio] Biochemistry, Molecular Biology Genomics [q-bio.GN] Life Sciences [q-bio] Microbiology and Parasitology Bacteriology
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