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Journal articles
A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response
Abstract : Intracellular pathogens such as $Listeria\ monocytogenes$ subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon IFN-stimulated genes (ISGs). IFN-$\lambda$ expression was induced in response to infection of epithelial cells with bacteria lacking LntA; however, the BAHD1-chromatin associated complex repressed downstream ISGs. In contrast, in cells infected with $lntA$-expressing bacteria, LntA prevented BAHD1 recruitment to ISGs and stimulated their expression. Murine listeriosis decreased in BAHD1$^{+/-}$ mice or when $lntA$ was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-$\lambda$-mediated immune response to control bacterial colonization of the host.
Cited literature [63 references]
https://hal-cea.archives-ouvertes.fr/cea-00819299
Contributor : Bruno Savelli <>
Submitted on : Sunday, July 26, 2020 - 6:01:03 PM
Last modification on : Tuesday, July 27, 2021 - 9:06:03 AM
Contributor : Bruno Savelli <>
Submitted on : Sunday, July 26, 2020 - 6:01:03 PM
Last modification on : Tuesday, July 27, 2021 - 9:06:03 AM
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Science_2011_post-print.pdf
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