 |
Journal articles
Condensation of actin filaments pushing against a barrier
Abstract : We develop a model to describe the force generated by the polymerization of an array of parallel biofilaments. The filaments are assumed to be coupled only through mechanical contact with a movable barrier. We calculate the filament density distribution and the force-velocity relation with a mean-field approach combined with simulations. We identify two regimes: a non-condensed regime at low force in which filaments are spread out spatially and a condensed regime at high force in which filaments accumulate near the barrier. We confirm a result previously known from other related studies, namely that the stall force is equal to N times the stall force of a single filament. In the model studied here, the approach to stalling is very slow, and the velocity is practically zero at forces significantly lower than the stall force.
keyword :
MICROTUBULES
Cited literature [23 references]
https://hal-cea.archives-ouvertes.fr/cea-00751507
Contributor : Marianne Leriche <>
Submitted on : Monday, May 13, 2013 - 7:00:05 AM
Last modification on : Tuesday, July 21, 2020 - 3:05:57 AM
Long-term archiving on: : Wednesday, August 14, 2013 - 2:20:09 AM
Contributor : Marianne Leriche <>
Submitted on : Monday, May 13, 2013 - 7:00:05 AM
Last modification on : Tuesday, July 21, 2020 - 3:05:57 AM
Long-term archiving on: : Wednesday, August 14, 2013 - 2:20:09 AM
File
1367-2630_13_10_103032.pdf
Publisher files allowed on an open archive