D. X. , X. Hu, D. , and I. Cea, Jouy en Josas, France) who contributed to the selection of probes for the SLA/PrV microarray, M Jérome Lecardonnel and Ms Céline

. Crepy, I. Crbgadie, J. Cea, I. Plateform, /. Jouy-en-josasdsv et al., France) for their technical assistance during the microarray experiment, Dr Claudia Bevilacqua (PICT Platform, INRA, Jouy-en-Josas, France) for her technical assistance during qRT-PCR experiments), who helps us during GEO submission process, and finally, ) and Dr Hélène Hayes) for the final read-through of the manuscript. References 1. Pomeranz LE, Reynolds AE, Hengartner CJ: Molecular biology of pseudorabies virus: impact on neurovirology and veterinary medicine, pp.462-500, 2005.

H. Nauwynck, S. Glorieux, H. Favoreel, and M. Pensaert, Cell biological and molecular characteristics of pseudorabies virus infections in cell cultures and in pigs with emphasis on the respiratory tract, Veterinary Research, vol.38, issue.2, pp.229-241, 2007.
DOI : 10.1051/vetres:200661

URL : https://hal.archives-ouvertes.fr/hal-00902845

T. Mettenleiter, Aujeszky's disease (pseudorabies) virus: the virus and molecular pathogenesis--state of the art, Vet Res, vol.31, pp.99-115, 1999.

B. Klupp, C. Hengartner, T. Mettenleiter, and L. Enquist, Complete, Annotated Sequence of the Pseudorabies Virus Genome, Journal of Virology, vol.78, issue.1, pp.424-440, 2004.
DOI : 10.1128/JVI.78.1.424-440.2004

A. Ambagala, J. Solheim, and S. Srikumaran, Viral interference with MHC class I antigen presentation pathway: The battle continues, Veterinary Immunology and Immunopathology, vol.107, issue.1-2, pp.1-15, 2005.
DOI : 10.1016/j.vetimm.2005.04.006

M. Mellencamp, O. Brien, P. Stevenson, and J. , Pseudorabies virusinduced suppression of major histocompatibility complex class I antigen expression, J Virol, vol.65, pp.3365-3368, 1991.

A. Ambagala, S. Hinkley, and S. Srikumaran, An Early Pseudorabies Virus Protein Down-Regulates Porcine MHC Class I Expression by Inhibition of Transporter Associated with Antigen Processing (TAP), The Journal of Immunology, vol.164, issue.1, pp.93-99, 2000.
DOI : 10.4049/jimmunol.164.1.93

D. Koppers-lalic, F. Rijsewijk, S. Verschuren, J. Gvb, A. Neisig et al., The UL41-encoded virion host shutoff (vhs) protein and vhs-independent mechanisms are responsible for down-regulation of MHC class I molecules by bovine herpesvirus 1, Journal of General Virology, vol.82, issue.9, pp.2071-2081, 2001.
DOI : 10.1099/0022-1317-82-9-2071

A. Ambagala, R. Gopinath, and S. Srikumaran, Inhibition of TAP by pseudorabies virus is independent of its vhs activity, Virus Research, vol.96, issue.1-2, pp.37-48, 2003.
DOI : 10.1016/S0168-1702(03)00171-0

A. Jansen and J. Yu, Differential gene expression of pathogens inside infected hosts, Current Opinion in Microbiology, vol.9, issue.2, pp.138-142, 2006.
DOI : 10.1016/j.mib.2006.01.003

R. Jenner and R. Young, Insights into host responses against pathogens from transcriptional profiling, Nature Reviews Microbiology, vol.77, issue.4, pp.281-294, 2005.
DOI : 10.1073/pnas.242741699

N. Ray and L. Enquist, Transcriptional Response of a Common Permissive Cell Type to Infection by Two Diverse Alphaherpesviruses, Journal of Virology, vol.78, issue.7, pp.3489-3501, 2004.
DOI : 10.1128/JVI.78.7.3489-3501.2004

A. Brukman and L. Enquist, Suppression of the Interferon-Mediated Innate Immune Response by Pseudorabies Virus, Journal of Virology, vol.80, issue.13, pp.6345-6356, 2006.
DOI : 10.1128/JVI.00554-06

Y. Blanchard, M. Le, C. Le, P. Blanchard, J. Leger et al., Cellular gene expression survey of PseudoRabies Virus (PRV) infected Human Embryonic Kidney cells (HEK-293), Veterinary Research, vol.37, issue.5, pp.705-723, 2006.
DOI : 10.1051/vetres:2006027

URL : https://hal.archives-ouvertes.fr/hal-00702098

C. Tuggle, Y. Wang, and O. Couture, Advances in Swine Transcriptomics, International Journal of Biological Sciences, vol.3, pp.132-152, 2007.
DOI : 10.7150/ijbs.3.132

C. Renard, E. Hart, H. Sehra, H. Beasley, P. Coggill et al., The genomic sequence and analysis of the swine major histocompatibility complex, Genomics, vol.88, issue.1, pp.96-110, 2006.
DOI : 10.1016/j.ygeno.2006.01.004

S. Zhao, J. Recknor, J. Lunney, D. Nettleton, D. Kuhar et al., Validation of a first-generation long-oligonucleotide microarray for transcriptional profiling in the pig, Genomics, vol.86, issue.5, pp.618-625, 2005.
DOI : 10.1016/j.ygeno.2005.08.001

T. Ledger, P. Pinton, D. Bourges, P. Roumi, H. Salmon et al., Development of a Macroarray To Specifically Analyze Immunological Gene Expression in Swine, Clinical and Vaccine Immunology, vol.11, issue.4, pp.691-698, 2004.
DOI : 10.1128/CDLI.11.4.691-698.2004

A. Bonnet, E. Iannuccelli, K. Hugot, F. Benne, M. Bonaldo et al., A pig multi-tissue normalised cDNA library: large-scale sequencing, cluster analysis and 9K micro-array resource generation, BMC Genomics, vol.9, issue.1, p.17, 2008.
DOI : 10.1186/1471-2164-9-17

URL : https://hal.archives-ouvertes.fr/cea-00307571

P. Bryant, D. Venter, R. Robins-browne, and N. Curtis, Chips with everything: DNA microarrays in infectious diseases, The Lancet Infectious Diseases, vol.4, issue.2, pp.100-111, 2004.
DOI : 10.1016/S1473-3099(04)00930-2

H. Hossain, S. Tchatalbachev, and T. Chakraborty, Host gene expression profiling in pathogen???host interactions, Current Opinion in Immunology, vol.18, issue.4, pp.422-429, 2006.
DOI : 10.1016/j.coi.2006.05.018

F. Lovegrove, L. Pena-castillo, N. Mohammad, W. Liles, T. Hughes et al., Simultaneous host and parasite expression profiling identifies tissue-specific transcriptional programs associated with susceptibility or resistance to experimental cerebral malaria, BMC Genomics, vol.7, issue.1, p.295, 2006.
DOI : 10.1186/1471-2164-7-295

Y. Zhang, J. Ohyashiki, T. Takaku, N. Shimizu, and K. Ohyashiki, Transcriptional profiling of Epstein???Barr virus (EBV) genes and host cellular genes in nasal NK/T-cell lymphoma and chronic active EBV infection, British Journal of Cancer, vol.60, issue.4, pp.599-608, 2006.
DOI : 10.1046/j.1365-2141.2003.04359.x

B. Zhu, G. Ping, Y. Shinohara, Y. Zhang, and Y. Baba, Comparison of gene expression measurements from cDNA and 60-mer oligonucleotide microarrays, Genomics, vol.85, issue.6, pp.657-665, 2005.
DOI : 10.1016/j.ygeno.2005.02.012

H. Wang, R. Malek, A. Kwitek, A. Greene, T. Luu et al., Assessing unmodified 70-mer oligonucleotide probe performance on glass-slide microarrays, Genome Biology, vol.4, issue.1, p.5, 2003.
DOI : 10.1186/gb-2003-4-1-r5

S. Stingley, J. Ramirez, S. Aguilar, K. Simmen, R. Sandri-goldin et al., Global Analysis of Herpes Simplex Virus Type 1 Transcription Using an Oligonucleotide-Based DNA Microarray, Journal of Virology, vol.74, issue.21, pp.9916-9927, 2000.
DOI : 10.1128/JVI.74.21.9916-9927.2000

P. Kennedy, E. Grinfeld, M. Craigon, K. Vierlinger, D. Roy et al., Transcriptomal analysis of varicella-zoster virus infection using long oligonucleotide-based microarrays, Journal of General Virology, vol.86, issue.10, pp.2673-2684, 2005.
DOI : 10.1099/vir.0.80946-0

H. Lin, Y. Chang, M. Wong, J. Lin, and T. Chang, Functional analysis of virion host shutoff protein of pseudorabies virus, Virology, vol.324, issue.2, pp.412-418, 2004.
DOI : 10.1016/j.virol.2004.04.015

Q. Lam, C. Smibert, K. Koop, C. Lavery, J. Capone et al., Herpes simplex virus VP16 rescues viral mRNA from destruction by the virion host shutoff function, EMBO J, vol.15, pp.2575-2581, 1996.

R. Abele and R. Tampe, Modulation of the antigen transport machinery TAP by friends and enemies, FEBS Letters, vol.174, issue.4, pp.1156-1163, 2006.
DOI : 10.1016/j.febslet.2005.11.048

E. Wiertz, R. Devlin, H. Collins, and M. Ressing, Herpesvirus Interference with Major Histocompatibility Complex Class II-Restricted T-Cell Activation, Journal of Virology, vol.81, issue.9, pp.4389-4396, 2007.
DOI : 10.1128/JVI.01525-06

K. Honda, A. Takaoka, and T. Taniguchi, Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors, Immunity, vol.25, issue.3, pp.349-360, 2006.
DOI : 10.1016/j.immuni.2006.08.009

A. Ciccaglione, E. Stellacci, C. Marcantonio, V. Muto, M. Equestre et al., Repression of Interferon Regulatory Factor 1 by Hepatitis C Virus Core Protein Results in Inhibition of Antiviral and Immunomodulatory Genes, Journal of Virology, vol.81, issue.1, pp.202-214, 2007.
DOI : 10.1128/JVI.01011-06

P. Lundberg, P. Welander, C. Edwards, R. Van, and E. Cantin, Tumor Necrosis Factor (TNF) Protects Resistant C57BL/6 Mice against Herpes Simplex Virus-Induced Encephalitis Independently of Signaling via TNF Receptor 1 or 2, Journal of Virology, vol.81, issue.3, pp.1451-1460, 2007.
DOI : 10.1128/JVI.02243-06

L. Andreeva, R. Heads, and C. Green, Cyclophilins and their possible role in the stress response, International Journal of Experimental Pathology, vol.336, issue.1, pp.305-315, 1999.
DOI : 10.1016/S0092-8674(00)81588-3

D. Braaten and J. Luban, Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells, The EMBO Journal, vol.20, issue.6, pp.1300-1309, 2001.
DOI : 10.1093/emboj/20.6.1300

K. Geenen, H. Favoreel, L. Olsen, L. Enquist, and H. Nauwynck, The pseudorabies virus US3 protein kinase possesses anti-apoptotic activity that protects cells from apoptosis during infection and after treatment with sorbitol or staurosporine, Virology, vol.331, issue.1, pp.144-150, 2005.
DOI : 10.1016/j.virol.2004.10.027

J. Stevens, G. Kado-boll, and C. Haven, Changes in nuclear basic proteins during pseudorabies virus infection, J Virol, vol.3, pp.490-497, 1969.

A. Poon, H. Gu, and B. Roizman, ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression, Proceedings of the National Academy of Sciences, vol.103, issue.26, pp.9993-9998, 2006.
DOI : 10.1073/pnas.0604142103

B. Feierbach, S. Piccinotti, M. Bisher, W. Denk, and L. Enquist, Alpha-Herpesvirus Infection Induces the Formation of Nuclear Actin Filaments, PLoS Pathogens, vol.154, issue.8, p.85, 2006.
DOI : 10.1371/journal.ppat.0020085.sv003

T. Pederson and U. Aebi, Nuclear Actin Extends, with No Contraction in Sight, Molecular Biology of the Cell, vol.16, issue.11, pp.5055-5060, 2005.
DOI : 10.1091/mbc.E05-07-0656

H. Favoreel, M. Van, D. Adriaensen, and H. Nauwynck, Cytoskeletal rearrangements and cell extensions induced by the US3 kinase of an alphaherpesvirus are associated with enhanced spread, Proceedings of the National Academy of Sciences, vol.102, issue.25, pp.8990-8995, 2005.
DOI : 10.1073/pnas.0409099102

A. Karger, J. Schmidt, and T. Mettenleiter, Infectivity of a pseudorabies virus mutant lacking attachment glycoproteins C and D

B. Riteau, V. De, and F. Lefevre, Trypsin increases pseudorabies virus production through activation of the ERK signalling pathway, Journal of General Virology, vol.87, issue.5, pp.1109-1112, 2006.
DOI : 10.1099/vir.0.81609-0

C. Muller, M. Denis, L. Gentzbittel, and T. Faraut, The Iccare web server: an attempt to merge sequence and mapping information for plant and animal species, Nucleic Acids Research, vol.32, issue.Web Server, pp.429-434, 2004.
DOI : 10.1093/nar/gkh460