Is ribosome synthesis controlled by pol I transcription? - Archive ouverte HAL Access content directly
Journal Articles Cell Cycle Year : 2007

Is ribosome synthesis controlled by pol I transcription?

(1) , (1) , (2) , (2) , (1) , (1)
1
2

Abstract

Regulation of growth ultimately depends on the control of synthesis of new ribosomes. Ribosome biogenesis is thus a key element of cell biology, which is tightly regulated in response to environmental conditions. In eukaryotic cells, the supply of ribosomal components involves the activities of the three forms of nuclear RNA polymerase (Pol I, Pol II and Pol III). Recently, we demonstrated that upon rapamycin treatment, a partial derepression of Pol I transcription led to a concomitant derepression of Pol II transcription restricted to a small subset of class II genes encompassing the genes encoding all ribosomal proteins, and 19 additional genes. The products of 14 of these 19 genes are principally involved in rDNA structure, ribosome biogenesis or translation, whereas the five remaining genes code for hypothetical proteins. We demonstrate that the proteins encoded by these five genes are required for optimal pre-rRNA processing. In addition, we show that cells in which regulation of Pol I transcription was specifically impaired are either resistant or hypersensitive to different stresses compared to wild-type cells. These results highlight the critical role of the regulation of Pol I activity for the physiology of the cells.
Fichier principal
Vignette du fichier
ChedinCellCycle2007_6-1.pdf (569.73 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

cea-00279105 , version 1 (14-05-2008)

Identifiers

  • HAL Id : cea-00279105 , version 1
  • PUBMED : 17245116

Cite

Stéphane Chédin, Arnaud Laferté, Tran Hoang, Denis L J Lafontaine, Michel Riva, et al.. Is ribosome synthesis controlled by pol I transcription?. Cell Cycle, 2007, 6 (1), pp.11-5. ⟨cea-00279105⟩

Collections

CEA
76 View
238 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More