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C-fos and c-myc modulation, mitogenic effect and Ia expression in the P388D1 murine macrophage line treated by immunomodifiers.

Abstract : The aim of the present study was to investigate whether the early modulation of the c-fos and c-myc oncogenes could give some orientation to the impact of immunomodulators on the monocyte-macrophage lineage. In order to work in a homogeneous system we used the P388D1 mouse macrophage cell-line which is considered as an almost mature macrophage. When P388D1 cells were stimulated by LPS, interferon-gamma or the association of both compounds, no direct correlation could be found between the modulation of DNA synthesis and the early expression of the c-fos and c-myc oncogenes. The positive regulation of Ia antigen expression seemed to correlate with the absence of induction of c-fos oncogene.
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https://hal-cea.archives-ouvertes.fr/cea-00274272
Contributor : Magali Le Discorde <>
Submitted on : Thursday, April 17, 2008 - 4:11:28 PM
Last modification on : Friday, March 27, 2020 - 2:21:20 AM

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  • HAL Id : cea-00274272, version 1
  • PUBMED : 1426675

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Magali Le Discorde, Y. C. Le Garrec, E. H. Jullian, P. J. Michel, A. J. Pompidou. C-fos and c-myc modulation, mitogenic effect and Ia expression in the P388D1 murine macrophage line treated by immunomodifiers.. Dev Biol Stand, 1992, 77, pp.65-70. ⟨cea-00274272⟩

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