T. De-lange, Shelterin: the protein complex that shapes and safeguards human telomeres, Genes & Development, vol.19, issue.18, pp.2100-2110, 2005.
DOI : 10.1101/gad.1346005

J. D. Griffith, L. Comeau, S. Rosenfield, R. M. Stansel, A. Bianchi et al., Mammalian Telomeres End in a Large Duplex Loop, Cell, vol.97, issue.4, pp.503-514, 1999.
DOI : 10.1016/S0092-8674(00)80760-6

T. K. Pandita, ATM function and telomere stability, Oncogene, vol.61, issue.4, pp.611-618, 2002.
DOI : 10.1038/sj.onc.1205060

Y. Shiloh, ATM and related protein kinases: safeguarding genome integrity, Nature Reviews Cancer, vol.12, issue.3, pp.155-168, 2003.
DOI : 10.1038/nrc1011

P. J. Hurley and F. Bunz, ATM and ATR: Components of an Integrated Circuit, Cell Cycle, vol.6, issue.4, pp.414-417, 2007.
DOI : 10.4161/cc.6.4.3886

T. K. Pandita, H. B. Lieberman, D. S. Lim, S. Dhar, W. Zheng et al., Ionizing radiation activates the ATM kinase throughout the cell cycle, Oncogene, vol.19, issue.11, pp.1386-1391, 2000.
DOI : 10.1038/sj.onc.1203444

C. J. Bakkenist and M. B. Kastan, DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation, Nature, vol.268, issue.6922, pp.499-506, 2003.
DOI : 10.1089/027245700429864

M. F. Lavin and S. Kozlov, ATM Activation and DNA Damage Response, Cell Cycle, vol.6, issue.8, pp.931-942, 2007.
DOI : 10.4161/cc.6.8.4180

U. Herbig, W. A. Jobling, B. P. Chen, D. J. Chen, and J. M. Sedivy, Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a, Molecular Cell, vol.14, issue.4, pp.501-513, 2004.
DOI : 10.1016/S1097-2765(04)00256-4

H. Takai, A. Smogorzewska, and T. De-lange, DNA Damage Foci at Dysfunctional Telomeres, Current Biology, vol.13, issue.17, pp.1549-1556, 2003.
DOI : 10.1016/S0960-9822(03)00542-6

URL : http://doi.org/10.1016/s0960-9822(03)00542-6

E. L. Denchi and T. De-lange, Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1, Nature, vol.18, issue.7157, pp.1068-1071, 2007.
DOI : 10.1038/nature06065

L. B. Smilenov, S. E. Morgan, W. Mellado, S. G. Sawant, M. B. Kastan et al., Influence of ATM function on telomere metabolism, Oncogene, vol.15, issue.22, pp.2659-2665, 1997.
DOI : 10.1038/sj.onc.1201449

B. Undarmaa, S. Kodama, K. Suzuki, O. Niwa, and M. Watanabe, X-ray-induced telomeric instability in Atm-deficient mouse cells, Biochemical and Biophysical Research Communications, vol.315, issue.1, pp.51-58, 2004.
DOI : 10.1016/j.bbrc.2004.01.014

L. B. Smilenov, S. Dhar, and T. K. Pandita, Altered Telomere Nuclear Matrix Interactions and Nucleosomal Periodicity in Ataxia Telangiectasia Cells before and after Ionizing Radiation Treatment, Molecular and Cellular Biology, vol.19, issue.10, pp.6963-6971, 1999.
DOI : 10.1128/MCB.19.10.6963

H. Scherthan, M. Jerratsch, S. Dhar, Y. A. Wang, S. P. Goff et al., Meiotic Telomere Distribution and Sertoli Cell Nuclear Architecture Are Altered in Atm- and Atm-p53-Deficient Mice, Molecular and Cellular Biology, vol.20, issue.20, pp.7773-7783, 2000.
DOI : 10.1128/MCB.20.20.7773-7783.2000

R. E. Verdun, L. Crabbe, C. Haggblom, and J. Karlseder, Functional Human Telomeres Are Recognized as DNA Damage in G2 of the Cell Cycle, Molecular Cell, vol.20, issue.4, pp.551-561, 2005.
DOI : 10.1016/j.molcel.2005.09.024

R. E. Verdun and J. Karlseder, The DNA Damage Machinery and Homologous Recombination Pathway Act Consecutively to Protect Human Telomeres, Cell, vol.127, issue.4, pp.709-720, 2006.
DOI : 10.1016/j.cell.2006.09.034

R. E. Verdun and J. Karlseder, Replication and protection of telomeres, Nature, vol.16, issue.7147, pp.924-931, 2007.
DOI : 10.1038/nature05976

Y. Wang and D. J. Patel, Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex, Structure, vol.1, issue.4, pp.263-282, 1993.
DOI : 10.1016/0969-2126(93)90015-9

G. N. Parkinson, M. P. Lee, and S. Neidle, Crystal structure of parallel quadruplexes from human telomeric DNA, Nature, vol.5, issue.6891, pp.876-880, 2002.
DOI : 10.1038/nature755

S. Neidle and G. N. Parkinson, The structure of telomeric DNA, Current Opinion in Structural Biology, vol.13, issue.3, pp.275-283, 2003.
DOI : 10.1016/S0959-440X(03)00072-1

L. Kelland, Targeting the Limitless Replicative Potential of Cancer: The Telomerase/Telomere Pathway, Clinical Cancer Research, vol.13, issue.17, pp.4960-4963, 2007.
DOI : 10.1158/1078-0432.CCR-07-0422

A. De-cian, L. Lacroix, C. Douarre, N. Temime-smaali, C. Trentesaux et al., Targeting telomeres and telomerase, Biochimie, vol.90, issue.1, pp.131-155, 2008.
DOI : 10.1016/j.biochi.2007.07.011

URL : https://hal.archives-ouvertes.fr/tel-00440832

G. Pennarun, C. Granotier, L. R. Gauthier, D. Gomez, F. Hoffschir et al., Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands, Oncogene, vol.12, issue.18, pp.2917-2928, 2005.
DOI : 10.1038/sj.onc.1208468

C. Granotier, G. Pennarun, L. Riou, F. Hoffschir, L. R. Gauthier et al., Preferential binding of a G-quadruplex ligand to human chromosome ends, Nucleic Acids Research, vol.33, issue.13, pp.4182-4190, 2005.
DOI : 10.1093/nar/gki722

D. S. Biard, E. Despras, A. Sarasin, and J. F. Angulo, Development of New EBV-Based Vectors for Stable Expression of Small Interfering RNA to Mimick Human Syndromes: Application to NER Gene Silencing, Molecular Cancer Research, vol.3, issue.9, pp.519-529, 2005.
DOI : 10.1158/1541-7786.MCR-05-0044

D. S. Biard, Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones, Nucleic Acids Research, vol.35, issue.11, pp.3535-3550, 2007.
DOI : 10.1093/nar/gkm195

P. Bertrand, A. T. Akhmedov, F. Delacote, A. Durrbach, and B. S. Lopez, Human POMp75 is identified as the pro-oncoprotein TLS/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation, Oncogene, vol.18, issue.31, pp.4515-4521, 1999.
DOI : 10.1038/sj.onc.1203048

B. Dutrillaux and J. Couturier, La Pratique de L'analyse Chromosomique, 1981.

P. M. Lansdorp, N. P. Verwoerd, F. M. Van-de-rijke, V. Dragowska, M. T. Little et al., Heterogeneity in telomere length of human chromosomes, Human Molecular Genetics, vol.5, issue.5, pp.685-691, 1996.
DOI : 10.1093/hmg/5.5.685

T. K. Pandita and D. Derubeis, Spontaneous amplification of interstitial telomeric bands in Chinese hamster ovary cells, Cytogenetic and Genome Research, vol.68, issue.1-2, pp.95-101, 1995.
DOI : 10.1159/000133899

E. Goodwin and J. Meyne, Strand-specific FISH reveals orientation of chromosome 18 alphoid DNA, Cytogenetic and Genome Research, vol.63, issue.2, pp.126-127, 1993.
DOI : 10.1159/000133516

C. M. Incles, C. M. Schultes, H. Kempski, H. Koehler, L. R. Kelland et al., A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells, Mol. Cancer Ther, vol.3, pp.1201-1206, 2004.

C. Leonetti, S. Amodei, C. Angelo, A. Rizzo, B. Benassi et al., -kl]acridinium methosulfate) is associated with telomere capping alteration, Mol. Pharmacol, vol.3843, issue.66, pp.11-613, 2004.
URL : https://hal.archives-ouvertes.fr/hal-01282450

M. P. Hande, A. S. Balajee, A. Tchirkov, A. Wynshaw-boris, and P. M. Lansdorp, Extra-chromosomal telomeric DNA in cells from Atm-/- mice and patients with ataxia-telangiectasia, Human Molecular Genetics, vol.10, issue.5, pp.519-528, 2001.
DOI : 10.1093/hmg/10.5.519

M. Van-overbeek and T. De-lange, Apollo, an Artemis-Related Nuclease, Interacts with TRF2 and Protects Human Telomeres in S Phase, Current Biology, vol.16, issue.13, pp.1295-1302, 2006.
DOI : 10.1016/j.cub.2006.05.022

X. D. Zhu, L. Niedernhofer, B. Kuster, M. Mann, J. H. Hoeijmakers et al., ERCC1/XPF Removes the 3??? Overhang from Uncapped Telomeres and Represses Formation of Telomeric DNA-Containing Double Minute Chromosomes, Molecular Cell, vol.12, issue.6, pp.1489-1498, 2003.
DOI : 10.1016/S1097-2765(03)00478-7

R. T. Abraham, Cell cycle checkpoint signaling through the ATM and ATR kinases, Genes & Development, vol.15, issue.17, pp.2177-2196, 2001.
DOI : 10.1101/gad.914401

S. M. Bailey, M. A. Brenneman, and E. H. Goodwin, Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells, Nucleic Acids Research, vol.32, issue.12, pp.3743-3751, 2004.
DOI : 10.1093/nar/gkh691

E. P. Rogakou, D. R. Pilch, A. H. Orr, V. S. Ivanova, and W. M. Bonner, DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139, Journal of Biological Chemistry, vol.273, issue.10, pp.5858-5868, 1998.
DOI : 10.1074/jbc.273.10.5858

L. Y. Hao, M. A. Strong, and C. W. Greider, Phosphorylation of H2AX at Short Telomeres in T Cells and Fibroblasts, Journal of Biological Chemistry, vol.279, issue.43, pp.45148-45154, 2004.
DOI : 10.1074/jbc.M403924200

O. Fernandez-capetillo, A. Lee, M. Nussenzweig, and A. Nussenzweig, H2AX: the histone guardian of the genome, DNA Repair, vol.3, issue.8-9, pp.959-967, 2004.
DOI : 10.1016/j.dnarep.2004.03.024

F. Di-fagagna, P. M. Reaper, L. Clay-farrace, H. Fiegler, P. Carr et al., A DNA damage checkpoint response in telomere-initiated senescence, Nature, vol.426, issue.6963, pp.194-198, 2003.
DOI : 10.1038/nature02118

T. Stiff, M. Driscoll, N. Rief, K. Iwabuchi, M. Lobrich et al., ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation, Cancer Research, vol.64, issue.7, pp.2390-2396, 2004.
DOI : 10.1158/0008-5472.CAN-03-3207

URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.323.5411

I. M. Ward and J. Chen, Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress, J. Biol. Chem, vol.276, pp.47759-47762, 2001.

A. Smogorzewska, J. Karlseder, H. Holtgreve-grez, A. Jauch, and T. De-lange, DNA Ligase IV-Dependent NHEJ of Deprotected Mammalian Telomeres in G1 and G2, Current Biology, vol.12, issue.19, pp.1635-1644, 2002.
DOI : 10.1016/S0960-9822(02)01179-X

R. C. Wang, A. Smogorzewska, and T. De-lange, Homologous Recombination Generates T-Loop-Sized Deletions at Human Telomeres, Cell, vol.119, issue.3, pp.355-368, 2004.
DOI : 10.1016/j.cell.2004.10.011

URL : http://doi.org/10.1016/j.cell.2004.10.011

C. Philippe, P. Coullin, and A. Bernheim, Double telomeric signals on single chromatids revealed by FISH and PRINS, Ann. Genet, vol.42, pp.202-209, 1999.

A. M. Olovnikov, A theory of marginotomy, Journal of Theoretical Biology, vol.41, issue.1, pp.181-190, 1973.
DOI : 10.1016/0022-5193(73)90198-7

V. L. Makarov, Y. Hirose, and J. P. Langmore, Long G Tails at Both Ends of Human Chromosomes Suggest a C Strand Degradation Mechanism for Telomere Shortening, Cell, vol.88, issue.5, pp.657-666, 1997.
DOI : 10.1016/S0092-8674(00)81908-X

S. Burge, G. N. Parkinson, P. Hazel, A. K. Todd, and S. Neidle, Quadruplex DNA: sequence, topology and structure, Nucleic Acids Research, vol.34, issue.19, pp.5402-5415, 2006.
DOI : 10.1093/nar/gkl655

URL : http://doi.org/10.1093/nar/gkl655