Shelterin: the protein complex that shapes and safeguards human telomeres, Genes & Development, vol.19, issue.18, pp.2100-2110, 2005. ,
DOI : 10.1101/gad.1346005
Mammalian Telomeres End in a Large Duplex Loop, Cell, vol.97, issue.4, pp.503-514, 1999. ,
DOI : 10.1016/S0092-8674(00)80760-6
ATM function and telomere stability, Oncogene, vol.61, issue.4, pp.611-618, 2002. ,
DOI : 10.1038/sj.onc.1205060
ATM and related protein kinases: safeguarding genome integrity, Nature Reviews Cancer, vol.12, issue.3, pp.155-168, 2003. ,
DOI : 10.1038/nrc1011
ATM and ATR: Components of an Integrated Circuit, Cell Cycle, vol.6, issue.4, pp.414-417, 2007. ,
DOI : 10.4161/cc.6.4.3886
Ionizing radiation activates the ATM kinase throughout the cell cycle, Oncogene, vol.19, issue.11, pp.1386-1391, 2000. ,
DOI : 10.1038/sj.onc.1203444
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation, Nature, vol.268, issue.6922, pp.499-506, 2003. ,
DOI : 10.1089/027245700429864
ATM Activation and DNA Damage Response, Cell Cycle, vol.6, issue.8, pp.931-942, 2007. ,
DOI : 10.4161/cc.6.8.4180
Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a, Molecular Cell, vol.14, issue.4, pp.501-513, 2004. ,
DOI : 10.1016/S1097-2765(04)00256-4
DNA Damage Foci at Dysfunctional Telomeres, Current Biology, vol.13, issue.17, pp.1549-1556, 2003. ,
DOI : 10.1016/S0960-9822(03)00542-6
URL : http://doi.org/10.1016/s0960-9822(03)00542-6
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1, Nature, vol.18, issue.7157, pp.1068-1071, 2007. ,
DOI : 10.1038/nature06065
Influence of ATM function on telomere metabolism, Oncogene, vol.15, issue.22, pp.2659-2665, 1997. ,
DOI : 10.1038/sj.onc.1201449
X-ray-induced telomeric instability in Atm-deficient mouse cells, Biochemical and Biophysical Research Communications, vol.315, issue.1, pp.51-58, 2004. ,
DOI : 10.1016/j.bbrc.2004.01.014
Altered Telomere Nuclear Matrix Interactions and Nucleosomal Periodicity in Ataxia Telangiectasia Cells before and after Ionizing Radiation Treatment, Molecular and Cellular Biology, vol.19, issue.10, pp.6963-6971, 1999. ,
DOI : 10.1128/MCB.19.10.6963
Meiotic Telomere Distribution and Sertoli Cell Nuclear Architecture Are Altered in Atm- and Atm-p53-Deficient Mice, Molecular and Cellular Biology, vol.20, issue.20, pp.7773-7783, 2000. ,
DOI : 10.1128/MCB.20.20.7773-7783.2000
Functional Human Telomeres Are Recognized as DNA Damage in G2 of the Cell Cycle, Molecular Cell, vol.20, issue.4, pp.551-561, 2005. ,
DOI : 10.1016/j.molcel.2005.09.024
The DNA Damage Machinery and Homologous Recombination Pathway Act Consecutively to Protect Human Telomeres, Cell, vol.127, issue.4, pp.709-720, 2006. ,
DOI : 10.1016/j.cell.2006.09.034
Replication and protection of telomeres, Nature, vol.16, issue.7147, pp.924-931, 2007. ,
DOI : 10.1038/nature05976
Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex, Structure, vol.1, issue.4, pp.263-282, 1993. ,
DOI : 10.1016/0969-2126(93)90015-9
Crystal structure of parallel quadruplexes from human telomeric DNA, Nature, vol.5, issue.6891, pp.876-880, 2002. ,
DOI : 10.1038/nature755
The structure of telomeric DNA, Current Opinion in Structural Biology, vol.13, issue.3, pp.275-283, 2003. ,
DOI : 10.1016/S0959-440X(03)00072-1
Targeting the Limitless Replicative Potential of Cancer: The Telomerase/Telomere Pathway, Clinical Cancer Research, vol.13, issue.17, pp.4960-4963, 2007. ,
DOI : 10.1158/1078-0432.CCR-07-0422
Targeting telomeres and telomerase, Biochimie, vol.90, issue.1, pp.131-155, 2008. ,
DOI : 10.1016/j.biochi.2007.07.011
URL : https://hal.archives-ouvertes.fr/tel-00440832
Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands, Oncogene, vol.12, issue.18, pp.2917-2928, 2005. ,
DOI : 10.1038/sj.onc.1208468
Preferential binding of a G-quadruplex ligand to human chromosome ends, Nucleic Acids Research, vol.33, issue.13, pp.4182-4190, 2005. ,
DOI : 10.1093/nar/gki722
Development of New EBV-Based Vectors for Stable Expression of Small Interfering RNA to Mimick Human Syndromes: Application to NER Gene Silencing, Molecular Cancer Research, vol.3, issue.9, pp.519-529, 2005. ,
DOI : 10.1158/1541-7786.MCR-05-0044
Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones, Nucleic Acids Research, vol.35, issue.11, pp.3535-3550, 2007. ,
DOI : 10.1093/nar/gkm195
Human POMp75 is identified as the pro-oncoprotein TLS/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation, Oncogene, vol.18, issue.31, pp.4515-4521, 1999. ,
DOI : 10.1038/sj.onc.1203048
La Pratique de L'analyse Chromosomique, 1981. ,
Heterogeneity in telomere length of human chromosomes, Human Molecular Genetics, vol.5, issue.5, pp.685-691, 1996. ,
DOI : 10.1093/hmg/5.5.685
Spontaneous amplification of interstitial telomeric bands in Chinese hamster ovary cells, Cytogenetic and Genome Research, vol.68, issue.1-2, pp.95-101, 1995. ,
DOI : 10.1159/000133899
Strand-specific FISH reveals orientation of chromosome 18 alphoid DNA, Cytogenetic and Genome Research, vol.63, issue.2, pp.126-127, 1993. ,
DOI : 10.1159/000133516
A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells, Mol. Cancer Ther, vol.3, pp.1201-1206, 2004. ,
-kl]acridinium methosulfate) is associated with telomere capping alteration, Mol. Pharmacol, vol.3843, issue.66, pp.11-613, 2004. ,
URL : https://hal.archives-ouvertes.fr/hal-01282450
Extra-chromosomal telomeric DNA in cells from Atm-/- mice and patients with ataxia-telangiectasia, Human Molecular Genetics, vol.10, issue.5, pp.519-528, 2001. ,
DOI : 10.1093/hmg/10.5.519
Apollo, an Artemis-Related Nuclease, Interacts with TRF2 and Protects Human Telomeres in S Phase, Current Biology, vol.16, issue.13, pp.1295-1302, 2006. ,
DOI : 10.1016/j.cub.2006.05.022
ERCC1/XPF Removes the 3??? Overhang from Uncapped Telomeres and Represses Formation of Telomeric DNA-Containing Double Minute Chromosomes, Molecular Cell, vol.12, issue.6, pp.1489-1498, 2003. ,
DOI : 10.1016/S1097-2765(03)00478-7
Cell cycle checkpoint signaling through the ATM and ATR kinases, Genes & Development, vol.15, issue.17, pp.2177-2196, 2001. ,
DOI : 10.1101/gad.914401
Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells, Nucleic Acids Research, vol.32, issue.12, pp.3743-3751, 2004. ,
DOI : 10.1093/nar/gkh691
DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139, Journal of Biological Chemistry, vol.273, issue.10, pp.5858-5868, 1998. ,
DOI : 10.1074/jbc.273.10.5858
Phosphorylation of H2AX at Short Telomeres in T Cells and Fibroblasts, Journal of Biological Chemistry, vol.279, issue.43, pp.45148-45154, 2004. ,
DOI : 10.1074/jbc.M403924200
H2AX: the histone guardian of the genome, DNA Repair, vol.3, issue.8-9, pp.959-967, 2004. ,
DOI : 10.1016/j.dnarep.2004.03.024
A DNA damage checkpoint response in telomere-initiated senescence, Nature, vol.426, issue.6963, pp.194-198, 2003. ,
DOI : 10.1038/nature02118
ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation, Cancer Research, vol.64, issue.7, pp.2390-2396, 2004. ,
DOI : 10.1158/0008-5472.CAN-03-3207
URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.323.5411
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress, J. Biol. Chem, vol.276, pp.47759-47762, 2001. ,
DNA Ligase IV-Dependent NHEJ of Deprotected Mammalian Telomeres in G1 and G2, Current Biology, vol.12, issue.19, pp.1635-1644, 2002. ,
DOI : 10.1016/S0960-9822(02)01179-X
Homologous Recombination Generates T-Loop-Sized Deletions at Human Telomeres, Cell, vol.119, issue.3, pp.355-368, 2004. ,
DOI : 10.1016/j.cell.2004.10.011
URL : http://doi.org/10.1016/j.cell.2004.10.011
Double telomeric signals on single chromatids revealed by FISH and PRINS, Ann. Genet, vol.42, pp.202-209, 1999. ,
A theory of marginotomy, Journal of Theoretical Biology, vol.41, issue.1, pp.181-190, 1973. ,
DOI : 10.1016/0022-5193(73)90198-7
Long G Tails at Both Ends of Human Chromosomes Suggest a C Strand Degradation Mechanism for Telomere Shortening, Cell, vol.88, issue.5, pp.657-666, 1997. ,
DOI : 10.1016/S0092-8674(00)81908-X
Quadruplex DNA: sequence, topology and structure, Nucleic Acids Research, vol.34, issue.19, pp.5402-5415, 2006. ,
DOI : 10.1093/nar/gkl655
URL : http://doi.org/10.1093/nar/gkl655