A stochastic differential equation model for transcriptional regulatory networks. - Archive ouverte HAL Access content directly
Journal Articles BMC Bioinformatics Year : 2007

A stochastic differential equation model for transcriptional regulatory networks.

(1) ,
1

Abstract

BACKGROUND: This work explores the quantitative characteristics of the local transcriptional regulatory network based on the availability of time dependent gene expression data sets.The dynamics of the gene expression level are fitted via a stochastic differential equation model, yielding a set of specific regulators and their contribution. RESULTS: We show that a beta sigmoid function that keeps track of temporal parameters is a novel prototype of a regulatory function, with the effect of improving the performance of the profile prediction. The stochastic differential equation model follows well the dynamic of the gene expression levels. CONCLUSION: When adapted to biological hypotheses and combined with a promoter analysis, the method proposed here leads to improved models of the transcriptional regulatory networks.
Fichier principal
Vignette du fichier
a1471-2105-8-S5-S4.pdf (237.4 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

cea-00169532 , version 1 (04-09-2007)

Identifiers

Cite

Adriana Climescu-Haulica, Michelle D Quirk. A stochastic differential equation model for transcriptional regulatory networks.. BMC Bioinformatics, 2007, 8 Suppl 5, pp.S4. ⟨10.1186/1471-2105-8-S5-S4⟩. ⟨cea-00169532⟩

Collections

CEA
30 View
167 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More