A stochastic differential equation model for transcriptional regulatory networks.

Adriana Climescu-Haulica (1) , Michelle D Quirk

1 LBIM - Laboratoire Biologie-Informatique-Mathématique

BACKGROUND: This work explores the quantitative characteristics of the local transcriptional regulatory network based on the availability of time dependent gene expression data sets.The dynamics of the gene expression level are fitted via a stochastic differential equation model, yielding a set of specific regulators and their contribution. RESULTS: We show that a beta sigmoid function that keeps track of temporal parameters is a novel prototype of a regulatory function, with the effect of improving the performance of the profile prediction. The stochastic differential equation model follows well the dynamic of the gene expression levels. CONCLUSION: When adapted to biological hypotheses and combined with a promoter analysis, the method proposed here leads to improved models of the transcriptional regulatory networks.

Domaines: Bio-Informatique, Biologie Systémique [q-bio.QM]

Adriana Climescu-Haulica, Michelle D Quirk. A stochastic differential equation model for transcriptional regulatory networks.. BMC Bioinformatics, 2007, 8 Suppl 5, pp.S4. ⟨10.1186/1471-2105-8-S5-S4⟩. ⟨cea-00169532⟩