Multimodal RM and Optic Imaging using ultramagnetic liposomes to monitor a cancer therapy

Abstract : Magnetic liposomes present an opportunity for the development of theranostic systems. Ultra-magnetic liposomes (UML) are highly loaded with ultra-small particles of iron oxide (USPIO) and can accumulate in a biological area thanks to a magnet. The incorporation of a fluorophore such as cyanine 5.5 in the formulation of the UML forms a bimodal imaging agent (MRI and optic) to monitor the magnetic accumulation in the tumor. The addition of an antitumoral drug into the UML combined with the application of High Intensity Focused Ultrasounds (HIFU) in the tumor can be used for a specific release of the drug in the region of interest.
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https://www.hal.inserm.fr/inserm-01143980
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Caroline Thébault, Grégory Ramniceanu, Johanne Seguin, Aude Michel, Claire Beauvineau, et al.. Multimodal RM and Optic Imaging using ultramagnetic liposomes to monitor a cancer therapy. Journées RITS 2015, Mar 2015, Dourdan, France. p16-17 Section nanomédecine. ⟨inserm-01143980⟩

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