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Magnetic Hyperthermia on γ-Fe 2 O 3 @SiO 2 Core-Shell Nanoparticles for mi-RNA 122 Detection

Abstract : Magnetic hyperthermia on core-shell nanoparticles bears promising achievements, especially in biomedical applications. Here, thanks to magnetic hyperthermia, γ-Fe2O3 cores are able to release a DNA target mimicking the liver specific oncotarget miRNA-122. Our silica coated magnetic nanoparticles not only allow the grafting at their surface of a significant number of oligonucleotides but are also shown to be as efficient, by local heating, as 95 °C global heating when submitted to an alternative magnetic field, while keeping the solution at 28 °C, crucial for biological media and energy efficiency. Moreover, a slight modification of the silica coating process revealed an increased heating power, well adapted for the release of small oligonucleotides such as microRNA. View Full-Text
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Submitted on : Thursday, January 14, 2021 - 4:43:42 PM
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Marie-Charlotte Horny, Jean Gamby, Vincent Dupuis, Jean-Michel Siaugue. Magnetic Hyperthermia on γ-Fe 2 O 3 @SiO 2 Core-Shell Nanoparticles for mi-RNA 122 Detection. Nanomaterials, MDPI, 2021, 11 (1), pp.149. ⟨10.3390/nano110101149⟩. ⟨hal-03110589⟩

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