Liposomes for PET and MR imaging and for dual targeting (magnetic field/glucose moiety): synthesis, properties and in vivo studies

Abstract : We describe the potentiality of a new liposomal formulation enabling PET and MR imaging for cancer diagnosis. The bimodality is achieved by coupling a 68Ga-based radiotracer on the bilayer of ultra magnetic liposomes. In order to enhance the targeting properties obtained under a permanent magnetic field, a sugar moiety was added in the lipid formulation. Two new phospholipids were synthesized, one with a specific chelator of 68Ga (DSPE-PEG-NODAGA) and one with a glucose moiety (DSPE-PEG-Glucose). The liposomes were produced according to a fast and safe process, with a high radiolabeling yield. MR and PET imaging were performed on mice bearing human glioblastoma tumors (U87MG) after iv injection. The accumulation of the liposomes in solid tumor is evidenced by MR imaging and the amount is evaluated in vivo and ex vivo according to PET imaging. An efficient magnetic targeting is achieved with these new magnetic liposomes.
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Jeremy Malinge, Bastien Géraudie, Paul Savel, Valerie Nataf, Aurelie Prignon, et al.. Liposomes for PET and MR imaging and for dual targeting (magnetic field/glucose moiety): synthesis, properties and in vivo studies. Molecular Pharmaceutics, American Chemical Society, 2016, 14 (2), pp.406-414. ⟨10.1021/acs.molpharmaceut.6b00794⟩. ⟨hal-01427809⟩

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