Skip to Main content Skip to Navigation
Journal articles

Formation and evolution of nanoscale calcium phosphate precursors under biomimetic conditions

Abstract : Simulated body fluids (SBFs) that mimic human blood plasma are widely used media for in vitro studies in an extensive array of research fields, from biomineralization to surface and corrosion sciences. We show that these solutions undergo dynamic nanoscopic conformational rearrangements on the timescale of minutes to hours, even though they are commonly considered stable or metastable. In particular, we find and characterize nanoscale inhomogeneities made of calcium phosphate (CaP) aggregates that emerge from homogeneous SBFs within a few hours and evolve into prenucleation species (PNS) that act as precursors in CaP crystallization processes. These ionic clusters consist of ∼2 nm large spherical building units that can aggregate into suprastructures with sizes of over 200 nm. We show that the residence times of phosphate ions in the PNS depend critically on the total PNS surface. These findings are particularly relevant for understanding nonclassical crystallization phenomena, in which PNS are assumed to act as building blocks for the final crystal structure.
Document type :
Journal articles
Complete list of metadata

https://hal.sorbonne-universite.fr/hal-03287574
Contributor : Hal Sorbonne Université Gestionnaire Connect in order to contact the contributor
Submitted on : Thursday, July 15, 2021 - 5:10:31 PM
Last modification on : Friday, July 16, 2021 - 1:18:50 PM
Long-term archiving on: : Saturday, October 16, 2021 - 6:59:29 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2022-01-15

Please log in to resquest access to the document

Identifiers

Citation

Ludovica Epasto, Tristan Georges, Jean-Michel Guigner, Albina Selimović, Thierry Azaïs, et al.. Formation and evolution of nanoscale calcium phosphate precursors under biomimetic conditions. Analytical Chemistry, American Chemical Society, 2021, ⟨10.1021/acs.analchem.1c01561⟩. ⟨hal-03287574⟩

Share

Metrics

Record views

65