First online X‐ray fluorescence characterization of liquid‐liquid extraction in microfluidics

Ange Maurice (1, 1) , Johannes Theisen (2) , Varun Rai (1, 1) , Fabien Olivier (1, 1) , Asmae El Maangar (2) , Jean Duhamet (3, 4, 5) , Thomas Zemb (2) , Jean-Christophe P. Gabriel (6, 7, 1)

1 Nanyang Technological University [Singapour]
2 ICSM - UMR 5257 - Institut de Chimie Séparative de Marcoule
3 CEA - Commissariat à l'énergie atomique et aux énergies alternatives
4 ISEC - Institut des Sciences et technologies pour une Economie Circulaire des énergies bas carbone
5 DMRC - Département de recherche sur les procédés pour la mine et le recyclage du combustible
6 CEA - CEA- Saclay
7 LICSEN UMR 3685 - Laboratoire Innovation en Chimie des Surfaces et NanoSciences

Aging entails an irreversible deceleration of physiological processes, altered metabolic activities, and a decline of the integrity of tissues, organs, and organ systems. The accumulation of alterations in the genetic and epigenetic spaces has been proposed as an explanation for aging. They result, at least in part, from DNA replication and chromosome segregation errors due to cell division during development, growth, renewal, and repair. Such deleterious alterations, including epigenetic drift, irreversibly accumulate in a stepwise, ratchet-like manner and reduce cellular fitness, similar to the process known as Muller’s ratchet. Here, we revisit the Muller’s ratchet principle applied to the aging of somatic cell populations and discuss the implications for understanding the origins of senescence, frailty, and morbidity

Domaines: Chimie analytique; Chimie

Ange Maurice, Johannes Theisen, Varun Rai, Fabien Olivier, Asmae El Maangar, et al.. First online X‐ray fluorescence characterization of liquid‐liquid extraction in microfluidics. Nano Select, 2021, 3 (2), pp.425-436. ⟨10.1002/nano.202100133⟩. ⟨cea-03274989v1⟩