Cellular senescence as a possible link between prostate diseases of the ageing male

Gaelle Fiard (1, 2, 3) , Vasilis Stavrinides (3) , Emma S Chambers (4) , Susan Heavey (3) , Alex Freeman (5) , Rhys Ball (5) , Arne N Akbar (5) , Mark Emberton (3)

1 Service d'urologie [CHU Grenoble]
2 TIMC-GMCAO - Gestes Medico-chirurgicaux Assistés par Ordinateur
3 Division of Surgery and Interventional Science [London, UK]
4 QMUL - Queen Mary University of London
5 UCL - University College of London [London]

Senescent cells accumulate with age in all tissues. Although senescent cells undergo cell-cycle arrest, these cells remain metabolically active and their secretomeknown as senescence-associated secretory phenotype (SASP)-is responsible for a systemic pro-inflammatory state, which contributes to an inflammatory microenvironment. Senescent cells can be found in the ageing prostate and the SASP and can be linked to benign prostatic hyperplasia and prostate cancer. Indeed, a number of signalling pathways provide biological plausibility for the role of senescence in both BPH and prostate cancer, although proving causality is difficult. The theory of senescence as a mechanism for prostate disease has a number of clinical implications, and could offer opportunities for targetting in the future.

Domaines: Urologie et Néphrologie; Organisation et fonctions cellulaires [q-bio.SC]

Gaelle Fiard, Vasilis Stavrinides, Emma S Chambers, Susan Heavey, Alex Freeman, et al.. Cellular senescence as a possible link between prostate diseases of the ageing male. Nature Reviews Urology, 2021, 18, pp.597-610. ⟨10.1038/s41585-021-00496-8⟩. ⟨hal-03313022⟩