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Welcome to the BREED publications collection
The Biology of Reproduction, Environment, Epigenetics and Development (BREED) joint research unit studies the effects of environment, in the broadest sense, on reproduction, development during embryonic and foetal life and the health of offspring. It gathers researchers, hospital clinicians and veterinarians for both agronomic and biomedical research.
The scientific context is based on the need to understand and control the mechanisms of epigenetic programming during prenatal life leading to the birth of a healthy, fertile and robust individual, capable of adapting to changes in its environment.
The aims of our research are to improve fertility and the efficiency of reproductive biotechnologies in humans and animals, to study the physiological and molecular mechanisms that determine the phenotypes of the offspring (health, growth, fertility, etc.) and to identify predictive and non-invasive biomarkers for these phenotypes, some of which could complement genetic selection strategies in animals. The unit relies on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, from the microscopic scale to the whole live animal. In vitro models are also developed as alternatives to animal experimentation (primary cell cultures, organoids, embryoids). This expertise and tools are complemented by clinical studies conducted by hospital and veterinary practitioners.
Last additions
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Amarnath Rambhatla, Rupin Shah, Imad Ziouziou, Priyank Kothari, Gianmaria Salvio, et al.. Global Practice Patterns and Variations in the Medical and Surgical Management of Non-Obstructive Azoospermia: Results of a World-Wide Survey, Guidelines and Expert Recommendations. The World Journal of Men's Health, 2024, 42, ⟨10.5534/wjmh.230339⟩. ⟨hal-04569819⟩
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Nicolas Jovanovic, Vicente Mustieles, Marc Althuser, Sarah Lyon-Caen, Nadia Alfaidy, et al.. Associations between synthetic phenols, phthalates, and placental growth/function: a longitudinal cohort with exposure assessment in early pregnancy. Human Reproduction Open, 2024, 2024 (2), pp.hoae018. ⟨10.1093/hropen/hoae018⟩. ⟨hal-04569675⟩
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Géraldine Porcu-Buisson, Chloé Maignien, Nelly Swierkowski-Blanchard, Catherine Rongières, Noémie Ranisavljevic, et al.. Prospective multicenter observational real-world study to assess the use, efficacy and safety profile of follitropin delta during IVF/ICSI procedures (DELTA Study). European Journal of Obstetrics & Gynecology and Reproductive Biology, 2024, 293, pp.21-26. ⟨10.1016/j.ejogrb.2023.12.011⟩. ⟨inserm-04391221⟩
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Rossella Cannarella, Rupin Shah, Ramadan Saleh, Florence Boitrelle, Taha Abo-Almagd Abdel-Meguid Hamoda, et al.. Effects of Varicocele Repair on Sperm DNA Fragmentation and Seminal Malondialdehyde Levels in Infertile Men with Clinical Varicocele: A Systematic Review and Meta-Analysis. The World Journal of Men's Health, 2024, 42, ⟨10.5534/wjmh.230235⟩. ⟨hal-04402641⟩
References
2 230
Open Access
33 %
Keywords
Trophoblast
Diesel
BIOLOGIE DU DEVELOPPEMENT
Fetal programming
Oxidative stress
Méthylation
Poulain
Male infertility
Infertility
Sheep
Animal models
Jument
Foxl2
Mare
Conceptus
DOHaD
Implantation
Embryo
Ovary
Endomètre
Equine
Embryo transfer
Pregnancy
Development
Transcriptome
Souris
IMMUNOLOGIE
Sexual dimorphism
Bovine
Uterus
Animal modèle
Animal model
Dairy cow
IMAGERIE
Spermatogenesis
Ovaire
Humans
Dohad
GENOMIQUE
BIOTECHNOLOGIE
Développement embryonnaire
Rabbit
Alimentation
Horse
Cattle
Bovin
Gestation
Somatic cell nuclear transfer
Environment
Épigénétique
Mice
Obesity
Ruminant
Développement
Dna methylation
Obésité
PLACENTA
Adult
Gene expression
Reproduction
Blastocyst
Cheval
These
GENETIQUE
Sperm
Lapin
Programmation foetale
Epigenetic
Embryon
Growth
Female
Meiosis
Epigenetics
Mouse
Endometrium
Progesterone
NUCLEAR TRANSFER
Fertilité
Placenta
Oocyte
EMBRYO
Spermatozoa
Methylation
Epigénétique
Mammary gland
IMAGE
Métabolisme
Nuclear transfer
Sex determination
Inflammation
Pluripotency
Foetus
Chorion
Nutrition
DNA methylation
Programming
Phénotype
Goat
Male
Fertility